CCN2 and neoplasm: These cells establish a favorable environment for tumor development by releasing cytokines (IL-6, IL-10 and TGF-β), metalloproteinases (MMP3 and MMP9) and growth factors (HGF, EGF, CTGF and IGF-1), leading to immunomodulation, angiogenesis, invasion, proliferation and tumor cell survival [15,16,17].