SDHB and Familial gastric cancer: In patients with Hereditary Diffuse Gastric Cancer who were negative for the CDH1 mutation, other germline mutations have been discovered including BRCA2, STK11 (serine/threonine kinase 11; Peutz–Jeghers syndrome), ATM (Ataxia–Telangiectasia mutated), SDHB (succinate dehydrogenase complex iron sulfur subunit B), PRSS1 (Serine protease 1; Hereditary pancreatitis syndrome), MSR1 (macrophage scavenger receptor 1), CTNNA1 (catenin alpha 1) and PALB2 (Partner and localizer of BRCA2) [5,12].