Vitamin C has been shown to inhibit the H. pylori mediated activation of NF-κB and STAT3, and promote tumour suppression in AGS cells in vitro by upregulating transmembrane protein with epidermal growth factor (EGF)-like and two follistatin motifs 2 (TMEFF2); and AGS apoptosis by mitochondrial mediated pathways [84]. Here, STAT3 is linked to neoplasm.