Our hypotheses in favor of RAS pathway over-activation as one of the main causes in determining COVID-19 susceptibility and severity, is completely in line with the recently GWAS identified associations of ABO and SLC6A20 loci [89] being crucial modifiers of Ang-II local levels and water/salt reabsorption [2,95,119,120,121]. Here, SLC6A20 is linked to COVID-19.