A recent report on an ACE1 I/D and ACE2 G8790A combined analysis hypothesized that high ACE1 activity (i.e., ACE1 D/D-genotype) together with low ACE2 activity (i.e., ACE2 G/G-females or hemizygous G-males) could be considered a high-risk combination for hypertension in presence of cardiovascular risk factors, old age, dyslipidemia and diabetes [72]. The gene discussed is ACE2; the disease is metabolic syndrome.