Of note, wide sex and racial differences in the frequency of ACE1 and ACE2 gene variants have been reported [26,27], and selected haplotypes cluster in fragile subgroups of patients at high risk of COVID-19 poor prognosis (e.g., male sex, Black ethnicity, cardiovascular disease), and interestingly, they seem to overlap COVID-19 morbidity and mortality rates [2,28,29,30,31,32]. Here, ACE2 is linked to COVID-19.