ACE and COVID-19: The recent SARS-CoV-2 pandemic fired-up again the interest on ACE1 I/D polymorphism, and despite the several recent investigations, definite results are still lacking [2,29,30,31,32], though a recent paper ascribed an ACE1 I/I-genotype inverse relation to SARS-CoV-2 related mortality, disclosing exciting correspondences between geographic ACE1 genotype distribution and COVID-19 morbidity and/or mortality [28] (Table 1).