This corroborates the hypothesis that, as for the ACE1 gene, selected haplotypes linked to high ACE2 expression might influence SARS-Cov-2 CFR among different populations according to the protective role of ACE2 against multifactorial thrombosis [74,75], endothelial dysfunction [76] and severe acute lung failure [2,77]. Here, ACE2 is linked to endothelial dysfunction.