ACE2 and COVID-19: More recently, five additional SNPs (rs1514283, rs4646155, rs4646176, rs2285666 and rs879922) in the ACE2 gene have been reported to be associated with essential hypertension in women of the Chinese Han population during the COVID-19 outbreak [84], though the association with hypertension exhibited high heterogeneity and varies with geographical, ethnic and gender also among the Chinese population [85].