Among the members of the Serine/Threonine CK1 family, CK1ε is able to transfer γ-phosphate groups from ATP to specific Ser and Thr residues of various substrates [5] and represents an important regulator of key molecular pathways whose dysregulation has been frequently reported in several type of cancers, as well as neurodegenerative diseases [36,37,38]. The gene discussed is CSNK1A1; the disease is cancer.