Recent studies have reported that this role seems to be played in cooperation with the human DDX3X protein, a DEAD-box ATPase/RNA helicase acting in several molecular pathways associated with normal biological processes, such as RNA metabolism, transcription, translation, cell proliferation, innate immunity, as well as pathological scenarios, as cancer, neurodegenerative diseases and viral infections [23,24,25]. Here, DDX3X is linked to viral infectious disease.