In contrast, siRNA disruption during infection reduced the expression of viral sensor genes RIG-I and MDA5, possibly leading to the downregulation of downstream responders of IFN induction such as IFN-β, MxA, OAS1, and IFIT1 (Interferon-Induced Protein with Tetratricopeptide Repeats 1). The gene discussed is IFIT1; the disease is infection.