KEAP1 presented mutations in GBC and HCC cell lines (blue circle and orange circle, respectively, in Figure 1a and MutationMapper in Figure 1b), and TGBC1 and TGBC2 shared the nonsynonymous variant that translated into the amino acid change p.E219Q (damaging according to SIFT and probably damaging according to PolyPhen-2; Table S3c). This evidence concerns the gene KEAP1 and hepatocellular carcinoma.