ACVRL1 and hereditary hemorrhagic telangiectasia: We next focused our interest on miRNA-10a and miRNA-214 because both are predicted to target ENG or ALK1, and their dysregulated expression in HHT patients with pulmonary AVMs (pAVMs) has been reported [26] Thus, ENG has been revealed, by MicroCosm and Target Scan, as a confident target of miRNA-214.