According to pathological findings of affected AD brain regions, two different types of aggregates are commonly found in the intracellular and extracellular compartments—the intracellular aggregates are known as NFTs and the extracellular aggregates are known as senile plaques that consist of insoluble paired helical filaments of hyperphosphorylated tau protein [19,20]. Here, MAPT is linked to Alzheimer disease.