CASP1 and infection: Whereas DENV viral protein NS2B interacts directly with cGAS and facilitates its degradation through an autophagy–lysosome-dependent mechanism, ZIKV NS1 is found to actively recruit deubiquitinase (DUB) USP8 and remove the K11-linked ubiquitin chains at the lysine 134 position of caspase-1, thus increasing the stability of caspase-1 and the cleavage of cGAS during infection [82,87].