IDH1 and infantile convulsions and choreoathetosis: In addition to the above-mentioned benefits favouring ctDNA-based molecular profiling in the absence of sufficient tissue, adequate concordance between tissue and ctDNA findings for patients with paired samples was demonstrated in this study (100% for FGFR2 and IDH1 alterations, which are currently of the most clinical relevance and interest in patients with iCCA in particular).