BRAF and neoplasm: Microsatellite “stable” BRAF-mutated CRCs share some features with MSI and BRAF-wild-type forms, such as proximal colon location and mucin production, but they usually affect younger patients with no difference in gender and show more aggressive morphological behavior, such as frequent tumor budding, lymphatic, perineural, and vascular invasion and early lymph node metastases [139].