Recently, in the BEACON trial [149], an open-label, phase III trial, it has been demonstrated that a combination of encorafenib, cetuximab and binimetinib (triplet-therapy group) resulted in a higher response rate and higher overall survival in patients with metastatic CRC with the V600E BRAF mutations if compared with the standard therapy, i.e., cetuximab and irinotecan or cetuximab and FOLFIRI. Here, BRAF is linked to colorectal carcinoma.