Cardiac hypertrophy is defined as an enlargement of the heart wall with an increase in the volume of cardiomyocytes; there are two forms of cardiac hypertrophy, namely, physiological, as occurs in response to exercise, and pathological, as occurs in response to abnormal stress, such as hypertension, pressure overload, endocrine disorders, myocardial infarction, and contractile dysfunction from inherited mutations in sarcomeric or cytoskeletal proteins [15,16]. The gene discussed is DNM2; the disease is cardiac hypertrophy.