Similarly, cell cycle dysregulation in CRC is associated with cyclin D1 dysregulation, and a variable frequency of cyclin D1 dysregulation in CRC has been reported according to the types of structural and genetic variants: CCDN1 amplification (2.5%) [5], cyclin D1 overexpression (55%) [6], and genomic aberrations called D-cyclin-activating features (DCAFs, <10 %) [7]. Here, CCND1 is linked to colorectal carcinoma.