We have recently shown that endogenous wild-type human VAV2, which is overexpressed in many hnSCC samples and hnSCC patient-derived cells [11], is critical for the tumorigenic and metastatic properties of hnSCC cancer cell lines (SSC-25) and hnSCC patient-derived cells (VdH15, VdH01) when tested in orthotopic xenotransplant experiments in immunocompromised mice. Here, VAV2 is linked to cancer.