Notably, both the CD3 and CD163 staining in the PTA were positive mainly at the perivascular level, while in the TC, the same staining could be largely found inside the parenchyma, thus indicating a preferential infiltration of CD3+ and CD163+ cells into the tumor tissue when compared to the periphery, probably due to a strong recruitment exerted by the GBM cells. The gene discussed is CD163; the disease is glioblastoma.