In GBM05, the high expression of IDO was accompanied by a relevant positivity for CD163 in the TC; the positivity for these markers is often co-localized in the cytoplasm of M2-like TAMs in GBM as previously shown in Figure 2 and Figure 3, suggesting the generation of an immunosuppressive macrophage profile induced by neoplastic cells the in tumor core of this GBM. The gene discussed is IDO1; the disease is neoplasm.