Of the 5 drugs targeting SLC7A11, riluzole, a noncompetitive metabotropic glutamate receptor 1 (mGluR1) antagonist, and sulfasalazine, a cystine/glutamate antiporter system xc-inhibitor used to treat inflammatory bowel disease and arthritis, have antitumor properties [48,49,50]. Here, SLC7A11 is linked to inflammatory bowel disease.