CD274 and neoplasm: It was worth noting that downregulated DMEGs were also highly enriched in immune-related pathways, including leukocyte activation involved in immune response, granulocyte migration, T cell mediated immunity, graft-versus-host disease, suggesting that downregulated DMEGs were involved in regulating immune responses of “EGFR Wild Type/Low PD-L1 expression” NSCLC, and even the formation of tumor immune microenvironment (Figure 6B).