To evaluate the influence of genomic epigenetic changes on prognosis, we evaluated the prognostic power of DMEGs in “EGFR Wild Type/Low PD-L1 expression” NSCLC and a 4 DMEGs-based (PLCXD3, BAIAP2L2, NPR3, SNX10) prognostic model were identified using a LASSO regression analysis model. Here, CD274 is linked to non-small cell lung carcinoma.