YAP is one of the key components of the mechanosensing machinery, and it is increasingly being connected to PAH pathology [169,178]—for example, by being part of the pro-proliferative Hippo-YAP/Tafazzin- integrin-linked kinase 1 (TAZ- ILK1) circuit involved in mediating the hyperproliferation of vascular cells in PAH [169,179,180]. The gene discussed is ILK; the disease is pulmonary arterial hypertension.