This was exemplified by Von Felbert et al. (2016) and Amoury et al. (2016) demonstrating the specific phototoxic effect of SNAP-tag based PIT using the NIR PS IR700, which specifically enabled the diagnosis and tumor destruction of melanoma and breast cancer cells, respectively overexpressing EGFR, CSPG4, and epithelial cell adhesion molecule (EpCAM) receptors, using sub-nanomolar IC50 concentrations (32–165 nM) [17,36]. The gene discussed is EPCAM; the disease is melanoma.