Lastly, He et al. (2016) used nanotechnology to demonstrate the synergistic and systemic anti-tumor immune effects of oxaliplatin chemotherapy and pyropheophorbide–PDT in inducing the destruction of primary treated and untreated colorectal tumor metastases, which is mediated by increased CRT and IFN-gamma producing CD8+ T cells [139]. Here, CALR is linked to neoplasm.