The roles played by SNAT2 in cancer rewiring may be various: (i) providing cells with proline for epigenetic control; (ii) providing cells with glutamine for energy metabolism; (iii) providing amino acids for signaling purposes merging the function of SLC38A9 in the lysosomal membrane; (iv) accumulating amino acids for protein synthesis and energy metabolism due to the concentrative transport mechanism (Figure 2). This evidence concerns the gene SLC38A2 and cancer.