Taken together, all the above observations, the main function of LAT1 in the context of cancer rewiring should be that of mediating the uptake of (i) leucine for the regulation of protein synthesis, mTORC1 signaling and glutamine utilization; (ii) methionine for DNA methylation and methionine cycle; (iii) BCAAs for Acetyl-CoA production and then lipogenesis and/or ATP production (Figure 2). Here, SLC7A5 is linked to cancer.