SLC1A5 and cancer: A greater number of studies has been conducted in cancer cell models showing that (i) loss of the tumor suppressor pRb causes the over-expression of ASCT2 through E2F-3 transcription factor [151], (ii) the proto-oncogene c-Myc induces overexpression of ASCT2 through a responsive element on ASCT2 promoter [152].