In addition to the role of self-renewal and differentiation modulators, the brain-specific miR-153 is preferentially expressed in neurons [89] and it was shown to downregulate SNCA protein levels [34], which play important roles in the pathogenesis of PD; whereas the miR-324-5p/3p inhibits proliferation while promoting neural differentiation of murine cerebellar granule cell progenitors (GCPs) into mature granule cells by antagonizing Hedgehog signaling [90]. This evidence concerns the gene SNCA and Parkinson disease.