Although the abovementioned experiment was conducted on cancer cell lines, in respect of autoimmunity, these outcomes might be interesting because of the treatment with IL-6 inhibitors of various rheumatic diseases, such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) [167], lupus, Crohn’s disease [168] and necessity of alternative strategies when resistance to biologics drug develop. This evidence concerns the gene IL6 and rheumatoid arthritis.