VEGFA and neoplasm: Furthermore, STAT3 is most strongly associated with the promotion of tumour growth and immunosuppression and is a bona fide oncogene, inducing the transcription of a broad panel of genes encoding regulators of cellular proliferation (such as cyclin D1 and c-Myc), survival (such as Bcl-XL and survivin) and angiogenesis (such as vascular endothelial growth factor (VEGF)) [142].