In patients with SSc, there is an increase of IL-1β in the serum and bronchoalveolar lavage fluid [65]; furthermore, in the lesion skin tissue of SSc patients, the expression levels of IL-1β are significantly upregulated and there is a positive association between dermal fibrosis severity evaluated by modified Rodnan skin score (mRSS) and IL-1β expression [66]. Here, IL1B is linked to systemic sclerosis.