SERPING1 and age-related macular degeneration: Eculizumab and C1-INH are joined by dozens of new complement-directed drugs that include small molecules, antibodies, biologics, peptides, and nucleotide-based therapies for the treatment of complement-related diseases, such as aHUS, C3G, PNH, antibody-mediated rejection, IgA nephropathy, age-related macular degeneration (AMD), and many others [7,17,18].