CXCR4 guided polyplexes composed of poly(lactic-co-glycolic acid) (PLGA), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-maleimide(polyethylene glycol)-2000 (DSPE-PEG-maleimide), equipped with a CXCR4 antagonist peptide for cell-specific targeting of HSC in liver fibrosis, have been developed (Table 2) [120]. Here, CXCR4 is linked to Hepatic fibrosis.