TGFB1 and cancer: TAM secrete an excess of some pro-inflammatory (e.g., IL-6, TNF-α), several anti-inflammatory (e.g., IL-10, TGFβ1) and pro-angiogenic (e.g., VEGF, FGF-2) factors and TME remodeling matrix metalloproteinases (MMPs), which together promote cancer growth, survival and metastasis.