TGFB1 and neoplasm: They support cancer development, growth, metastasis and resistance to chemo- or checkpoint inhibitor therapy by a multitude of mechanisms, including ECM remodeling, angiogenesis, active immunosuppression and secretion of tumor promoting cytokines, chemokines and growth factors such as EGF, HGF, CCL2, TGFβ1 and VEGF.