Patients with AF carrying 1 or 2 A alleles showed 5% lower trough concentration compared with homozygotes for ABCB1 single nucleotide polymorphisms (SNP) rs4148738 (G allele).[9] Gouin-Thibault et al[16] performed a haplotype combination analysis of ABCB1 SNP rs2032582 and rs1045642 and found that homozygous and heterozygous mutations increased the peak plasma concentration (Cmax) of dabigatran by 33% and 13%, respectively, and the AUC by 28% and 25%, respectively. This evidence concerns the gene ABCB1 and atrial fibrillation.