Similar to the FTO gene, the MC4R gene is also highly expressed in the central nervous system, which regulates the energy metabolism.[19] It was reported that MC4R may regulate food choice and intake, and energy expenditure through a distinct pathway.[20,21] However, further studies are needed to clarify the potential biological pathways through which these MC4R SNPs increase the risk of obesity and cancer. This evidence concerns the gene MC4R and obesity disorder.