The FSH/LH ratio could be used to differentiate between decreased and normal response cycles, and the elevated day-3 FSH/LH ratio was associated with an inferior outcome in IVF treatment cycles.[6–8] Oliveira et al[9] innovatively used ORPI to assess ovarian response and found that ORPI exhibited an excellent ability to predict poor or excessive ovarian response, a collection of greater than or equal to 4 metaphase II oocytes and the occurrence of pregnancy in infertile women. Here, PLOD1 is linked to Infertility.