CD4 and lymphopenia: The percentages of CD3+, CD4+ T cells, and NK cells, and the CD4/CD8 ratio of effective group (CR+PR) were markedly decreased compared with the ineffective radiotherapy group (SD+PD).[8] The ORR in cancer patients with pretreatment lymphopenia was significantly lower than in patients with normal lymphocyte counts.[29] In our study, we found that there were no significant differences in blood cell subsets between the effective and ineffective groups at three time points (Fig. 2).