SNRNP70 and Alzheimer disease: In a recent study of U1-70K, an snRNP consistently associated with NFTs in the AD brain, Bishof et al. utilized a network-based proteomic approach to functionally characterize the co-immunoprecipitated interactome of U1-70K and identify those protein–protein interactions most dependent on U1-70K domains implicated in aggregation and AD pathogenesis [138].