PICALM and Alzheimer disease: These associations between AD risk and oligodendrocyte function mirror the results of a recent large-scale transcriptomic network analysis in the human AD brain (DLPFC, visual cortex, cerebellum), which demonstrated significant enrichment of AD GWAS candidates in conserved disease-associated oligodendrocyte-enriched modules, including BIN1, PICALM, and several others [130].