Notably, HDAC‐1 knockdown showed a certain degree of cell differentiation, but there was no significant enhance of in the degree of differentiation after treatment of Baicalein, suggesting that the induction of differentiation of AML cells by Baicalein may depend on the inhibitory effect of HDAC‐1 (Figure 4A,B). The gene discussed is HDAC1; the disease is acute myeloid leukemia.