As for the variance of C/EBPα regulation by Baicalein, we speculated that Baicalein exerted upregulation of either p42 or p30 via the degradation effect of AML1‐ETO fusion protein in AML with t(8; 21), but the influence by Baicalein in modulating p42/p30 ratio made the expression of p30 finally showed a slight change. This evidence concerns the gene RUNX1T1 and acute myeloid leukemia.