The three sets of mutations from all 105 Cameroonian SCA patients (Figure 3A; Table S1) formed a network (Figure 3B) through gene hubs including HGF, PLAT [MIM: 173370], F5 [MIM: 612309], F2 [MIM: 176930], ESR2, INSR, RXRG [MIM: 180247], PMS1 [MIM: 600258], and MYOC [MIM: 601652]. This evidence concerns the gene ESR2 and autosomal dominant cerebellar ataxia.