Identification of genes such as LTC4S, that displayed specific signal of unusual difference in SNPs frequencies among patients with stoke (Figure S8A), will deserve future investigations with appropriate experimental design to explore other genes involved in leukotriene synthesis pathways, that have long been associated with SCD pain, airway hyperresponsiveness, and hospitalization rates.32, 33. Here, LTC4S is linked to Schnyder corneal dystrophy.