Herein, we showed that ATL‐1, a natural crude component of baizhu capable of suppressing cancer cell growth and self‐renewal, not only downregulated the expression of miR‐200c in colorectal CSCs, but also seemed to inhibit the uptake of miR‐200c‐containing EVs by CRC cells to prevent the conferral of metastatic properties. Here, ATL1 is linked to colorectal carcinoma.