We show that in untreated HIV-HBV co-infected individuals, while there were multiple associations observed, both liver fibrosis and liver enzyme abnormalities were significantly associated with increased intrahepatic mRNA for CXCL10 and its receptor CXCR3 and that expression of CXCL10 was primarily in hepatocytes. This evidence concerns the gene CXCL10 and Hepatic fibrosis.