Like protein-only recPrPSc, all three of these native strains can seed BV but not Mo PrPC substrate (Fig 7, top and third rows) (. Unlike BV PrPC, the BV(DR) chimera was unable to propagate Sc237, sheep scrapie, or CWD (Fig 7, second row). Conversely, unlike Mo PrPC, the Mo(ES) chimera was competent substrate for propagation of these three native strains (Fig 7, bottom row). The gene discussed is PRNP; the disease is scrapie.