Proliferation assays in 2 mouse and 4 human sarcoma cell lines, including one mouse and 3 human RMS cell lines, revealed growth inhibition by the proteasome inhibitor bortezomib, the CENPE inhibitor UA62784 and latrunculin A. Yet, interestingly, the multi-kinase inhibitor sorafenib increased in vitro proliferation of 5 of 6 sarcoma cell lines tested, including 3 human RMS cell lines. Here, CENPE is linked to sarcoma.