RYR2 and Huntington disease: To evaluate the remodeling and functional abnormalities of RyR2 in the brains of HD patients, cortical and hippocampal biopsies from deidentified organ donors (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.140614DS1) with neuropathological grade 3 and 4 HD, 5 female and 3 male (ages 54–66, CAG repeats 36–51), were obtained from the New York Brain Bank at Columbia University.