C3 and nephritis: Moreover, imiquimod-treated LckCreR2Dfl/fl mice developed less lupus-like nephritis, as evidenced by the decreased anti–dsDNA IgG levels in the serum (Figure 5H), proteinuria (Figure 5I), deposition of complement C3 and IgG in glomeruli (Figure 5, J and K; Supplemental Figure 5D), histologic signs of glomerulonephritis (Figure 5, L and M), and number of kidney-infiltrating lymphocytes (Figure 5N) when compared with those in the imiquimod-treated R2Dfl/fl mice.