SIRT1 and chronic obstructive pulmonary disease: 2020). Curcumin ameliorates COPD by promoting autophagy and inhibiting ERS through regulation of SIRT1 in COPD rats (Tang and Ling 2019). Melatonin inhibits cigarette smoke-induced inflammatory mediators by upregulating SIRT1 expression, thereby improving COPD (Shin et al. 2020).