INS and type 2 diabetes mellitus: Consistent with these results, Inzucchi et al found that 3 months of metformin treatment (1000 mg twice a day) increased insulin-stimulated peripheral glucose uptake by 13% along with a ~20% reduction in rates of HGP, resulting in a 58 mg/dL reduction in fasting plasma glucose concentration in patients with poorly controlled T2D (36).