ADAMTS7 and atherosclerosis: There, we postulated that vascular smooth muscle cells (VSMCs) of centenarians with the ADAMTS7 A variant may migrate into the endothelium of subcutaneous vessels, phagocytize oxidized LDL, stimulate hemichannel opening to release VLDL into the extracellular environment or adjacent cells, contributing to preventing the occurrence of atherosclerosis through the MAPK pathway.(Figure 3, Supplementary Figure 6).