DUSP4 and colorectal cancer: For online dataset analysis, GEPIA database (http://gepia.cancer-pku.cn/index.html) and Oncomine database (https://www.oncomine.org/) were adopted for evaluation, and it was found that DUSP4 expression was higher in colorectal cancer tissues than in the paired normal tissues (P<0.05) (Figure 1A and 1B).