To determine whether the SOS1 inhibitor BAY-293 could generally synergize with EGFR-TKIs in EGFR-mutated lung adenocarcinoma cells, we extended our assessment of drug-drug synergy to isobologram analysis (Figure 3) and Bliss independence analysis (Figure 4) in six different EGFR-mutated lung adenocarcinoma cell lines. This evidence concerns the gene SOS1 and lung adenocarcinoma.