MAP4K1 and neoplasm: Should further studies show that the complete removal of HPK1 is a superior approach to confer immune cells with more robust anti-tumor immunity, a number of approaches are available to eliminate the protein, such as clustered regularly interspaced short palindromic repeats (CRISPR), short hairpin RNAs (shRNA), antisense oligonucleotides (ASO) or Proteolysis Targeting Chimeras (PROTACs).