MAP4K1 and pancreatic ductal adenocarcinoma: As PanIN progresses to a more aggressive pancreatic ductal adenocarcinomas (PDAC), HPK1 expression is loss via CUL7/Fbxw8 ubiquitin ligase-dependent targeting of HPK1 for degradation via the 26 s proteasome (Wang et al., 2009; Wang et al., 2014).