However, since dendritic cells from neither the K46E HPK1 mice used by Hernandez et al. nor the dendritic cells from the K46M HPK1 mice used by Liu et al. were assessed for their ability to function in a cancer vaccine the way analogous HPK1-/- BMDCs were assessed (Liu et al., 2019; Hernandez et al., 2018), the relevance of HPK1 kinase activity in the regulation of cancer neoantigen presentation in the TME warrants further investigation. This evidence concerns the gene MAP4K1 and cancer.