BMP4 decreases during late childhood/young adulthood and then increases again during physiological aging (Meyers et al., 2016), as well as in pathological conditions including metabolic syndrome (Son et al., 2011), leukemia (Voeltzel et al., 2018) or bone fractures (van Baardewijk et al., 2013). This evidence concerns the gene BMP4 and leukemia.