FASN and Sepsis: First, C75, an inhibitor of fatty acid synthase (FASN), has been shown to stimulate fatty acid utilization by increasing the activity of carnitine palmitoyltransferase 1 (CPT1; the rate‐limiting enzyme in mitochondrial FAO) and to ameliorate liver injury in the caecal ligation and puncture models of sepsis 21, 23; however, the effects of C75 on the heart had never been investigated.