Moreover, we have demonstrated for the first time that CRC tumor growth, angiogenesis and liver metastasis are governed by circFNDC3B/miR‐937‐5p/TIMP3 axis through direct binding and elucidated that circFNDC3B or circFNDC3B exosomes induce TIMP3 to suppress angiogenesis to inhibit CRC progression by targeting miR‐937‐5p. The gene discussed is TIMP3; the disease is neoplasm.