In summary, we report in this study that circFNDC3B/miR‐937‐5p/TIMP3 axis governs CRC tumor progression, angiogenesis and liver metastasis and demonstrate that circFNDC3B induces TIMP3 to suppress angiogenesis to inhibit CRC progression by targeting miR‐937‐5p. This evidence concerns the gene TIMP3 and neoplasm.