To explore further the molecular roles of circFNDC3B and miR‐937‐5p in angiogenesis, we incubated HUVEC with CM collected from circFNDC3B overexpressing CRC cells with or without miR‐937‐5p mimics transfection, and observed that tube formation (Fig. 4C) and cell migration (Fig. 4D) abilities, as well as VEGFR expression (Fig. 4E), of HUVEC were greatly inhibited after the incubation with circFNDC3B overexpressing cell culture CM. The gene discussed is KDR; the disease is colorectal carcinoma.