Next, we tested whether inhibition of angiogenic properties induced by circFNDC3B in CRC cells were altered by TIMP3 knockdown, and observed that upon sh‐TIMP3 co‐transfection, the expression of VEGFA, which was reduced by circFNDC3B overexpression, was markedly restored at both mRNA (Fig. 9A) and protein (Fig. 9B) levels. Here, TIMP3 is linked to colorectal carcinoma.