Interestingly, angiogenesis proved by tube formation and VEGFR expression in HUVEC was also inhibited by circFNDC3B overexpression or circFNDC3B‐enriched exosomes, further confirming the tumor‐suppressive function of circFNDC3B in CRC progression by inhibition of the angiogenesis process. Here, KDR is linked to colorectal carcinoma.