During alveolar bone resorption in periodontitis, osteoclastogenesis is promoted via multiple signalling processes such as activation of NF-κB and induction of c-fos followed by RANKL binding to receptor activator of nuclear factor-kappa B (RANK).17 GJ inhibited osteoclast formation not only in ligature-induced periodontitis, but also in RANKL-stimulated RAW 264.7 cells. This evidence concerns the gene TNFSF11 and periodontitis.