Somatic and/or germline variants in numerous PI3K–AKT–mTOR pathway genes, including TSC2, TSC1, MTOR, PIK3CA, AKT3, RHEB, DEPDC5, NPRL3 and NPRL2, are known to be associated with malformations within the FCD–hemimegalencephaly spectrum55,135–139. This evidence concerns the gene DEPDC5 and hemimegalencephaly.