These in vitro data imply that AA may have utility as either a low-intensity preventive treatment in TET2MT CHIP or as a high dose treatment of MN48, consistent with promising in vivo effects of AA in murine models of TET2MT MN23,26, in particular, TET2/FLT3-ITD induced murine AML model23. This evidence concerns the gene STUB1 and acute myeloid leukemia.